Amphadase Hyaluronidase Injection 150 Units/1 mL Single-Dose Vials (10 Pack) **Refrigerated Item** (Rx)

Amphadase Hyaluronidase Injection 150 Units is used to enhance the absorption and dispersion of other injected medications. It works by breaking down hyaluronic acid, a component of connective tissue, to promote the spread of fluids or drugs and improve their effectiveness. This injection is often used to facilitate subcutaneous fluid administration, reduce tissue swelling, and aid in contrast agent diffusion in diagnostic procedures. By enhancing permeability, it ensures more efficient delivery of therapeutic agents.

Amphadase Hyaluronidase Injection by Amphastar Pharmaceuticals is a high-quality enzymatic adjuvant designed to enhance the absorption and dispersion of other injected drugs. Packaged in convenient single-dose vials, this hyaluronidase formulation is ideal for professional healthcare settings where precision and efficacy are paramount. Whether facilitating subcutaneous fluid administration or improving the intradermal spread of hypodermoclyses, Amphadase serves as an invaluable tool in medical practices, ensuring optimum therapeutic outcomes. Trust in Amphastar Pharmaceuticals for a product that exemplifies pharmaceutical excellence and reliability.

Product Details and Features:

• Unit Composition: Each vial contains 150 units of hyaluronidase in 1 mL, with 10 single-dose vials per pack.
  
• Refrigerated Product: Maintains stability and potency through proper refrigeration.
  
• Facilitates Drug Dispersion: By altering the permeability of connective tissue,
• Amphadase promotes increased absorption of co-administered drugs.
  Sterile and Ready-to-Administer: Presented in single-dose vials to ensure sterility and reduce contamination risks.
  
• Pharmaceutical-Grade Quality: Manufactured under stringent conditions to ensure safety and efficacy.

Mechanism of Action:

Hyaluronidase is an enzyme that catalyzes the hydrolysis of hyaluronic acid, a major component of the extracellular matrix in tissues. By breaking down hyaluronic acid, Amphadase temporarily decreases the viscosity of connective tissue, thereby enhancing the absorption and dispersion of injected fluids or medications. This mechanism facilitates rapid drug uptake and more efficient therapeutic interventions.

Directions for Use:

• Preparation: Ensure proper refrigeration until use and bring to room temperature prior to administration.
  
• Dosage and Administration: The precise dosage and method of administration should be determined by a healthcare professional based on the specific medical requirement. Inject as soon as is feasible after drawing into the syringe.
  
• Route of Administration: Administer via subcutaneous injection to facilitate drug absorption or spread.
  
• Compatibility: Amphadase can be co-administered with other injectable medications, assuming physical compatibility and stability.

Side Effects:

• Common Side Effects: Mild local reactions at the injection site, such as redness or swelling.
  
• Rare Side Effects: Allergic reactions, which may include symptoms like difficulty breathing, rash, or severe dizziness. Immediate medical attention is necessary if such reactions occur.
    
  Warnings:
• Hypersensitivity: Avoid use in individuals with known hypersensitivity to hyaluronidase or any of its components.
  
• Pregnancy and Nursing: Consultation with a healthcare provider is advisable before administration in pregnant or nursing women.
  
• Drug Interactions: Clinicians should consider potential interactions with other drugs being introduced concurrently.
  
• Refrigeration: Keep refrigerated to maintain product stability. Do not use if the product has been exposed to inappropriate temperatures or has been contaminated.
  
• Professional Use Only: Intended for use by qualified healthcare professionals.
• Ensure proper patient consultation regarding treatment specifics and potential reactions.

Choose Amphadase Hyaluronidase Injection by Amphastar Pharmaceuticals for exceptional quality and superior drug delivery enhancement in clinical settings, where reliability and patient safety are paramount.