{"product_id":"voriconazole-for-injection-200-mg-powder-vial-by-fosun-pharma-rx","title":"Voriconazole Injection 200 mg Powder Vial by Fosun Pharma (RX)","description":"Voriconazole injection is used to treat serious fungal infections, including invasive aspergillosis and certain serious Candida infections. It's typically used when oral treatment isn't feasible or for patients with weakened immune systems. Always follow your healthcare provider's guidance for its use.\n\u003cp\u003eVoriconazole for Injection 200 mg by Fosun Pharma is a sterile, lyophilized powder designed for reconstitution and intravenous administration. It contains the active antifungal agent, voriconazole, specifically formulated to treat severe fungal infections. Manufactured by Fosun Pharma, this medication meets stringent quality standards to ensure safety and efficacy. \u003c\/p\u003e\n\u003cp\u003eVoriconazole for Injection 200 mg\u003cbr\u003eManufacturer: Fosun Pharma\u003cbr\u003ePharmaceutical Form: Lyophilized Powder for Solution for Infusion\u003cbr\u003eActive Ingredient: Voriconazole (200 mg per vial)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEach vial contains 200 mg of voriconazole as a lyophilized powder. The product is usually supplied in sterilized glass vials sealed with a rubber stopper and an aluminum crimp seal with a flip-off cap.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVoriconazole is presented as a white to off-white lyophilized powder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVoriconazole for Injection is indicated for the treatment of several serious systemic fungal infections, including:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAcute invasive aspergillosis.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSevere infections caused by Scedosporium apiospermum.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSevere infections caused by Fusarium species.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFlucytosine-resistant and fluconazole-resistant serious Candida infections.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis antimicrobial agent is typically used in patients who have not responded to other antifungal treatments or who are intolerant to other therapies. It is especially crucial in immunocompromised patients, such as those undergoing hematopoietic stem cell transplantation or chemotherapy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVoriconazole is a triazole antifungal agent. It exerts its effect by inhibiting the enzyme 14α-sterol demethylase. This inhibition disrupts ergosterol synthesis, a vital component of fungal cell membranes, thereby compromising membrane integrity, growth, and replication of fungi.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Dosage:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVoriconazole for Injection must be reconstituted and further diluted for intravenous infusion. The dosage and duration of therapy should be guided by patient condition, type of infection, and response to treatment. Typical dosing instructions are as follows:\u003c\/p\u003e\n\u003cp\u003eInitial intravenous loading dose (Day 1): 6 mg\/kg every 12 hours for 24 hours.\u003cbr\u003eFollowing maintenance dose: 4 mg\/kg every 12 hours intravenously.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReconstitution and Dilution:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Reconstitute each vial with 19 ml of sterile water for injection to achieve a concentration of 10 mg\/ml.\u003cbr\u003e2. Gently shake the mixture to ensure complete dissolution.\u003cbr\u003e3. Further dilute the reconstituted solution with a compatible infusion fluid (e.g., 0.9% sodium chloride injection, 5% dextrose injection) to achieve a final voriconazole concentration of 0.5 - 5 mg\/ml for intravenous administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePharmacokinetics:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAbsorption:\u003c\/strong\u003e Rapidly distributed following injection.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDistribution: \u003c\/strong\u003eWidely distributed into tissues with high penetration into the cerebrospinal fluid.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolism:\u003c\/strong\u003e Extensively metabolized in the liver by the cytochrome P450 enzymes.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElimination:\u003c\/strong\u003e Primarily excreted through the urine, predominantly as metabolites.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Conditions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStore unopened vials at 20° to 25°C (68° to 77°F) in a dry place. \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eAfter reconstitution, unused solution must be discarded if not used within specified time frames, generally within 24 hours if stored under refrigeration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePrecautions and Contraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eContraindicated in patients with known hypersensitivity to voriconazole or to any of the components of the formulation.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCaution is advised in patients with hepatic or renal impairment.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVoriconazole can cause QT prolongation; use with caution in patients with pro-arrhythmic conditions.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRegular monitoring of liver function tests, renal function, and electrolyte levels is recommended.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNot recommended in pregnant and breastfeeding women unless the potential benefit justifies the potential risk to the fetus\/infant.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon side effects include, but are not limited to:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVisual disturbances\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFever\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRash\u003c\/li\u003e\n\u003cli\u003eNausea and vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eElevated liver enzymes\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFlushing and headache\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSerious but less common side effects may include severe liver impairment, severe cutaneous reactions, and cardiac arrhythmias.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003eVoriconazole for Injection 200 mg Powder Vial by Fosun Pharma is a critical antifungal medication for the treatment of severe and invasive fungal infections. Given under proper medical supervision, its clinical utility is invaluable in combating complicated mycotic diseases, especially in immunocompromised individuals where other treatments are ineffective or not tolerated. The administration must follow specific reconstitution and infusion protocols to ensure patient safety and drug efficacy.\u003c\/p\u003e","brand":"Fosun Pharma USA","offers":[{"title":"Default Title","offer_id":53337912705342,"sku":"72266-0131-01","price":5485.99,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0872\/3408\/5182\/files\/Voriconazole-for-Injection-200-mg-Powder-Vial-by-Fosun.jpg?v=1776780706","url":"https:\/\/himkhand.com\/products\/voriconazole-for-injection-200-mg-powder-vial-by-fosun-pharma-rx","provider":"Himkhand","version":"1.0","type":"link"}