{"product_id":"naltrexone-tablets-50-mg-precision-dose-100-count","title":"Naltrexone 50 mg Tablets 100 Count (RX)","description":"\u003ch1\u003eNaltrexone 50 mg Uses, Mechanism, Dosage, LDN, and Side Effects\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eNaltrexone is a \u003cstrong\u003elong-acting opioid receptor antagonist\u003c\/strong\u003e (a pure opiate blocker) available as a 50 mg oral tablet (brand names: ReVia®, Depade®, generics) and as a 380 mg monthly gluteal injection (Vivitrol®). It has high affinity for μ-opioid receptors (and to a lesser degree δ\/κ receptors) but no agonist effects. In practice, naltrexone \u003cstrong\u003eblocks the effects of opioids\u003c\/strong\u003e (preventing their euphoria and analgesia) and \u003cstrong\u003edampens alcohol’s rewarding effects\u003c\/strong\u003e by occupying opioid receptors released by endorphins. For example, a single 50 mg dose will block heroin or prescription opioid effects for ~24 hours. Naltrexone does not relieve pain or cause addiction itself, but displaces opioids; if opioids are still in the body, taking naltrexone will precipitate withdrawal.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eUses (Indications)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpioid Use Disorder (OUD):\u003c\/strong\u003e Naltrexone is FDA-approved for \u003cstrong\u003epreventing relapse in opioid-dependent patients\u003c\/strong\u003e who have completed detox and are opioid-free. It is prescribed in Medication-Assisted Treatment along with counseling. (Extended-release naltrexone IM is an alternative for patients who have difficulty with daily pills.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlcohol Use Disorder (AUD):\u003c\/strong\u003e FDA-approved to \u003cstrong\u003ereduce heavy drinking\u003c\/strong\u003e and relapse in alcohol-dependent patients. It is used \u003cem\u003eafter\u003c\/em\u003e alcohol detox is complete (to avoid vomiting), usually as 50 mg once daily. Naltrexone \u003cstrong\u003ereduces alcohol craving and reward\u003c\/strong\u003e by blocking alcohol-induced endorphin effects. It is \u003cem\u003enot\u003c\/em\u003e disulfiram – it does not cause nausea with drinking, but simply makes drinking less pleasurable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther approved\/experimental uses:\u003c\/strong\u003e A fixed-dose combo of naltrexone+bupropion is FDA-approved for obesity (as Contrave®). Off-label, naltrexone has been explored for impulse-control and eating disorders. Notably, \u003cstrong\u003elow-dose naltrexone (LDN)\u003c\/strong\u003e (~1–5 mg daily) is used experimentally for chronic pain and autoimmune conditions (e.g. fibromyalgia, Crohn’s disease, multiple sclerosis).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNaltrexone 50 mg\u003c\/strong\u003e \u003cstrong\u003eTablets \u003c\/strong\u003eare a prescription medication used primarily for:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlcohol dependence:\u003c\/strong\u003e To help people who have stopped drinking alcohol remain abstinent.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpioid dependence:\u003c\/strong\u003e To aid in the maintenance of opioid abstinence, following detoxification.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch2\u003eHow Naltrexone Works\u003c\/h2\u003e\n\u003cp\u003eNaltrexone acts as a \u003cstrong\u003ecompetitive antagonist at opioid receptors\u003c\/strong\u003e. By binding μ-opioid receptors, it \u003cstrong\u003eblocks any opioid agonist\u003c\/strong\u003e (heroin, morphine, oxycodone, etc.) from activating them. This prevents the usual opioid effects of euphoria, pain relief and respiratory depression. In clinical terms, taking naltrexone after opioids will precipitate immediate withdrawal, so patients must be opioid-free before starting.\u003c\/p\u003e\n\u003cp\u003eFor alcohol dependence, naltrexone’s blockade of opioid receptors interferes with alcohol’s reward circuitry. Alcohol normally triggers release of endogenous opioids (endorphins) that reinforce drinking. Naltrexone \u003cstrong\u003eblunts that endogenous opioid surge\u003c\/strong\u003e, thus reducing craving and the “reward” from alcohol. It modestly increases abstinence rates when combined with counseling.\u003c\/p\u003e\n\u003cp\u003ePharmacokinetics: Oral naltrexone is well absorbed (peak ~1–2 hours) but has ~5–40% bioavailability due to first-pass metabolism. It is metabolized to active 6-β-naltrexol and cleared mostly by the kidney. The 50 mg dose sustains μ-receptor blockade for ~24 hours; its terminal half-life is ~4 hours (75% of drug gone by 24h). The IM depot (380 mg) provides blockade for ~4 weeks.\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e50 mg oral tablet\u003c\/strong\u003e: The usual maintenance dose for both AUD and OUD is \u003cstrong\u003e50 mg once daily\u003c\/strong\u003e. Treatment generally starts at 25 mg (to test tolerance) and then increases to 50 mg after 1–2 days if no withdrawal or side effects occur. It can be taken with or without food (with meals may reduce GI upset).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOpioid detox requirement:\u003c\/strong\u003e Crucially, patients must be fully opioid-free (about 7–10 days after short-acting opioids) before starting naltrexone. Otherwise, naltrexone will trigger withdrawal. In practice a small “naloxone challenge” can verify the absence of opioids.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eIM Injection (380 mg):\u003c\/strong\u003e An extended-release monthly intramuscular injection is also available. It is administered deep in the gluteal region every 4 weeks. This depot is often used for patients who may not reliably take daily pills. The injection produces effective blockade for ~4 weeks and improves compliance in some patients.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAlcohol dependence:\u003c\/strong\u003e Similarly, 50 mg daily is standard, given in supervised doses or with family support. Therapy should emphasize continued sobriety; naltrexone will help attenuate heavy drinking if relapse occurs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePediatric use:\u003c\/strong\u003e Naltrexone is not approved for children or adolescents.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial populations:\u003c\/strong\u003e Dose adjustment is generally not required in mild\/moderate renal impairment. \u003cem\u003eHepatic caution:\u003c\/em\u003e Because naltrexone is hepatically metabolized, it should be avoided in acute hepatitis or liver failure. (Liver enzyme monitoring is advisable.) Withdrawal precautions apply if used in pregnant opioid users.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eLow-Dose Naltrexone (LDN):\u003c\/strong\u003e A very low nightly dose (typically 1.5–4.5 mg) is used off-label for pain\/autoimmune disorders. This “intermittent” blockade of opioid growth factor receptors may upregulate endorphins and modulate immune function. Protocols vary, but a common regimen is one 3 or 4.5 mg dose taken at bedtime. This use is supported by small trials and patient reports showing reductions in pain and fatigue (e.g. in fibromyalgia, Crohn’s, MS). It is not FDA-approved, but many integrative physicians prescribe LDN for refractory chronic conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSide Effects\u003c\/h2\u003e\n\u003cp\u003eNaltrexone’s side effects are generally mild and dose-related. Common adverse effects (≥10% incidence) include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eGastrointestinal:\u003c\/strong\u003e \u003cem\u003eNausea\u003c\/em\u003e (up to ~33%), \u003cem\u003evomiting\u003c\/em\u003e (~11–14%), \u003cem\u003ediarrhea\u003c\/em\u003e, \u003cem\u003eabdominal cramps\u003c\/em\u003e. Taking with food or at bedtime may ease nausea.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCNS:\u003c\/strong\u003e \u003cem\u003eHeadache\u003c\/em\u003e (~25%), \u003cem\u003einsomnia\u003c\/em\u003e (10–15%), \u003cem\u003edizziness\u003c\/em\u003e, \u003cem\u003eanxiety\u003c\/em\u003e (~12%), \u003cem\u003efatigue or low energy\u003c\/em\u003e, \u003cem\u003esleep disturbances\u003c\/em\u003e. These often lessen after a few weeks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAppetite\/weight:\u003c\/strong\u003e Decreased appetite (∼14%), which may be desirable in some overweight patients.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eMusculoskeletal:\u003c\/strong\u003e Muscle\/joint pain, back pain, or cramps are reported (6–12%).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePsychiatric:\u003c\/strong\u003e Mood changes can occur. In trials, depression was reported (~8%). Rare suicidal ideation has been noted (slightly above placebo rates). Patients with severe mental illness should be monitored closely for worsening mood or suicidality.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAllergies:\u003c\/strong\u003e Allergic reactions are rare. If rash, itching, or angioedema occur, discontinue naltrexone. A handful of urticarial\/angioedema cases have been reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eInjection site (Vivitrol only):\u003c\/strong\u003e The monthly IM formulation often causes injection-site pain, swelling, nodules or bruising (up to ~69%), which is usually mild and resolves.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eHepatic:\u003c\/strong\u003e Though uncommon at normal doses, \u003cem\u003eliver toxicity\u003c\/em\u003e is a serious potential effect. High doses (\u0026gt;300 mg\/day) have caused hepatic injury. Even patient’s long-term use can elevate transaminases. Liver function tests should be checked periodically, and naltrexone avoided (or used very cautiously) in active liver disease.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePrecipitated withdrawal:\u003c\/strong\u003e The most important “side effect” is precipitated opioid withdrawal. If naltrexone is taken while opioids are in the system, it can cause \u003cstrong\u003eacute withdrawal\u003c\/strong\u003e (nausea, vomiting, sweating, tachycardia, anxiety, muscle aches, piloerection, etc.). Hence, proper detoxification \u003cem\u003eand\u003c\/em\u003e a naloxone challenge are recommended before starting therapy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOther:\u003c\/strong\u003e Dry mouth, diarrhea, and rare cases of elevated CPK or heart rate changes have been documented. If patients experience unusual symptoms (e.g. severe abdominal pain, jaundice, chest pain, or seizures), naltrexone should be stopped and medical evaluation sought.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn summary, naltrexone (50 mg tablets) is a key “blocker” in addiction medicine – it prevents opioid euphoria and reduces alcohol craving. It is taken once daily as part of a comprehensive relapse prevention plan. Side effects are mostly gastrointestinal or headache and tend to be transient. The biggest risks are liver injury (dose-dependent) and precipitating withdrawal if misused. Low-dose naltrexone (1–5 mg) is an alternative regimen under research, thought to modulate immune factors, with generally mild side effects.\u003c\/p\u003e\n\u003ch3\u003eDetails and Features\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Naltrexone Hydrochloride 50 mg per tablet\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufacturer:\u003c\/strong\u003e Sun Pharmaceuticals\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackage Size:\u003c\/strong\u003e 100 count (bottle)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Oral tablet, scored for flexible dosing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Assured:\u003c\/strong\u003e Manufactured under stringent GMP guidelines\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e Yes\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFeatures:\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003eProven efficacy in relapse prevention\u003c\/li\u003e\n\u003cli\u003eEasy, once-daily oral dosing\u003c\/li\u003e\n\u003cli\u003eNon-addictive and non-narcotic\u003c\/li\u003e\n\u003cli\u003eConvenient bottle for long-term therapy\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eDirections for Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eTake exactly as prescribed by your healthcare provider.\u003c\/li\u003e\n\u003cli\u003eThe usual adult dose: \u003cstrong\u003e50 mg tablet taken once daily by mouth\u003c\/strong\u003e. Dosage may vary based on patient response and physician direction.\u003c\/li\u003e\n\u003cli\u003eSwallow tablets whole with a glass of water. May be taken with or without food.\u003c\/li\u003e\n\u003cli\u003eDo not attempt to self-medicate or adjust dosage without medical supervision.\u003c\/li\u003e\n\u003cli\u003eNaltrexone is most effective when used in conjunction with a structured recovery program.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003e\u003cstrong\u003eDosage\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdults (Opioid\/Alcohol Dependence):\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cem\u003eTypical dose:\u003c\/em\u003e 50 mg once daily, or as directed by your doctor.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMissed Dose:\u003c\/strong\u003e Take as soon as remembered. If it is almost time for your next dose, skip the missed dose. Do not double up to make up for a missed dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChildren:\u003c\/strong\u003e Not typically recommended for use in individuals under 18 years old unless directed by a physician.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eAllergies\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eDo not use\u003c\/strong\u003e if you have:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eKnown hypersensitivity to Naltrexone Hydrochloride or any component of this product.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSigns of allergic reaction:\u003c\/strong\u003e Rash, itching, swelling, severe dizziness, or trouble breathing — seek immediate medical attention.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eBe sure to inform your doctor about all medications and supplements you are taking, especially:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eOpioid medications (e.g., codeine, hydrocodone, oxycodone, morphine, heroin)\u003c\/li\u003e\n\u003cli\u003eCertain cough\/cold medications, antidiarrheal drugs, or pain relievers containing opioids\u003c\/li\u003e\n\u003cli\u003eDisulfiram (used for alcohol dependence)\u003c\/li\u003e\n\u003cli\u003eOther medications affecting the liver\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e Naltrexone will block the effects of opioid medications. Do not use opioids while taking this medication. Doing so may result in sudden withdrawal symptoms.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eSide Effects and Warnings\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003ePossible Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNausea, vomiting, stomach pain\u003c\/li\u003e\n\u003cli\u003eHeadache, dizziness, tiredness\u003c\/li\u003e\n\u003cli\u003eAnxiety, insomnia, or restlessness\u003c\/li\u003e\n\u003cli\u003eMuscle or joint pain\u003c\/li\u003e\n\u003cli\u003eDecreased appetite\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects (Seek medical attention immediately):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLiver toxicity: Yellowing eyes\/skin, dark urine, upper belly pain\u003c\/li\u003e\n\u003cli\u003eSevere allergic reactions: Rash, itching\/swelling, difficulty breathing\u003c\/li\u003e\n\u003cli\u003eInjection site reaction (if using the injectable form)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo not use Naltrexone if you are currently dependent on opioids\u003c\/strong\u003e or have not completed detoxification; can precipitate acute withdrawal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver Risk:\u003c\/strong\u003e Use with caution in patients with liver disease; regular liver function monitoring is recommended.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy\/Breastfeeding:\u003c\/strong\u003e Use only if benefits outweigh potential risks; consult your physician.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMedical Alert:\u003c\/strong\u003e Notify healthcare providers you are taking Naltrexone before surgery; special protocols may be needed for pain management.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNaltrexone Tablets 50 mg by are available by prescription only. Use strictly as directed by your healthcare provider. Always consult your doctor before starting, stopping, or changing your medication regimen.\u003c\/p\u003e","brand":"Precision Dose Inc.","offers":[{"title":"Default Title","offer_id":53337490227518,"sku":"68094-909-50P","price":13013.99,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0872\/3408\/5182\/files\/Naltrexone-Hydrochloride-Tablets-50-mg-Precision-Dose.jpg?v=1776771618","url":"https:\/\/himkhand.com\/products\/naltrexone-tablets-50-mg-precision-dose-100-count","provider":"Himkhand","version":"1.0","type":"link"}