{"product_id":"flumazenil-for-injection-5-ml-multiple-dose-vials-1-0-mg-ml-fresenius-kabi","title":"Flumazenil Injection 0.5 mg Per 5 mL (1.0 mg\/mL) Multiple Dose Vials 10\/Box by Fresenius Kabi (RX)","description":"\u003cp\u003eFlumazenil Injection is used to reverse the effects of benzodiazepines, particularly during cases of overdose or in situations requiring rapid recovery from sedation. As a benzodiazepine antagonist, it swiftly counteracts sedation and respiratory depression caused by these medications. This injection is crucial in emergency and critical care settings to restore consciousness and improve breathing in patients affected by benzodiazepine use. Administered by healthcare professionals, it enhances patient safety during medical procedures and overdose management.\u003c\/p\u003e\n\u003cp\u003eFresenius Kabi presents Flumazenil for Injection, a critical antidote designed for rapid reversal of benzodiazepine sedation and overdose. With a formulation of 0.5 mg per 5 mL (1.0 mg\/mL), this injectable solution comes in multiple dose vials, providing healthcare professionals with precise control over administration. Packaged in boxes containing 10 vials, this product ensures ample supply for medical settings where benzodiazepine influence must be promptly addressed, enhancing patient safety and recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConcentration and Formulation:\u003c\/strong\u003e Each 5 mL vial contains 0.5 mg of Flumazenil, giving a concentration of 1.0 mg\/mL, to facilitate titration based on individual patient needs.\u003cbr\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e Supplied in multiple-dose vials, arranged in boxes of 10, to accommodate both emergency responses and sedation reversal protocols in clinical practice.\u003cbr\u003e\u003cstrong\u003eAdministration Route:\u003c\/strong\u003e Intended for intravenous use, providing immediate onset of action critical for timely intervention in cases of benzodiazepine overdose or sedation reversal.\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Quickly and effectively reverses the sedative effects of benzodiazepines used in anesthesia or during medical procedures, and treats benzodiazepine overdoses in emergent situations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFlumazenil acts as a benzodiazepine receptor antagonist. By competitively inhibiting benzodiazepine binding on the gamma-aminobutyric acid (GABA) receptor complex, it blocks the depressant effects on the central nervous system. This blockade effectively reverses sedation, amnesia, and respiratory depression induced by benzodiazepines, restoring the patient’s baseline level of consciousness and respiratory function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeizure Risk:\u003c\/strong\u003e Flumazenil administration in certain patient populations, particularly those with benzodiazepine dependence or concurrent tricyclic antidepressant overdose, can precipitate seizures. Caution is advised with gradual and monitored dosage adjustments.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRe-Sedation Danger:\u003c\/strong\u003e Recurrent sedation may occur due to flumazenil’s shorter half-life compared to most benzodiazepines. Continuous monitoring post-administration is necessary until the resedative risk has passed.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity Reaction:\u003c\/strong\u003e Consider avoiding use in patients with a history of hypersensitivity to flumazenil or other benzodiazepine antagonists.\u003cbr\u003e\u003cstrong\u003eConcomitant Drug Use\u003c\/strong\u003e: Caution the use in patients with mixed-drug overdoses, as flumazenil is specific to benzodiazepines and does not reverse effects of non-benzodiazepine CNS depressants.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological:\u003c\/strong\u003e Dizziness, headache, or agitation following administration.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal:\u003c\/strong\u003e Nausea or vomiting post-injection.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Potential for tachycardia or hypertension in response to sudden CNS activity changes.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Site Reactions:\u003c\/strong\u003e Possible localized pain or discomfort at the site of administration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Considerations:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePatient Monitoring: \u003c\/strong\u003eEnsure continuous observation for signs of seizure activity or resedation, particularly in patients with histories of seizure disorders or chronic benzodiazepine usage.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfusion Rates and Protocols:\u003c\/strong\u003e Administer flumazenil slowly, titrating doses incrementally to minimize adverse reactions while achieving therapeutic effects.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComprehensive Assessment:\u003c\/strong\u003e A detailed evaluation of any potential risks related to benzodiazepine withdrawal, such as substance dependence or co-ingestant toxicity, is crucial prior to administration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFlumazenil for Injection by Fresenius Kabi is an essential medication for healthcare professionals in emergency or perioperative settings, enabling them to safely counteract benzodiazepine effects and ensure optimal patient care. Detailed prescribing information should be consulted to ensure comprehensive understanding and implementation of treatment protocols.\u003c\/p\u003e","brand":"Fresenius Kabi","offers":[{"title":"Default Title","offer_id":53335235592510,"sku":"63323-0424-05","price":18505.99,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0872\/3408\/5182\/files\/Flumazenil-Injection-0.5-mg-by-Fresenius-Kabi.jpg?v=1776754074","url":"https:\/\/himkhand.com\/products\/flumazenil-for-injection-5-ml-multiple-dose-vials-1-0-mg-ml-fresenius-kabi","provider":"Himkhand","version":"1.0","type":"link"}