{"product_id":"diphenhydramine-injection-50-mg-ml-single-dose-vials-1-ml-x-25-pack","title":"Diphenhydramine Injection 50 mg\/mL Single-Dose Vials 1 mL x 25\/Pack (RX)","description":"\u003ch1\u003eDiphenhydramine Injection 50 mg – Overview\u003c\/h1\u003e\n\u003cp\u003eDiphenhydramine injection is the injectable form of diphenhydramine hydrochloride (Benadryl), a first-generation H₁-antihistamine. It is supplied as a \u003cstrong\u003esterile, pyrogen-free solution\u003c\/strong\u003e at 50 mg per 1 mL (each 1 mL ampule contains 50 mg diphenhydramine HCl). As an antihistamine, it \u003cstrong\u003eblocks H₁ receptors\u003c\/strong\u003e and has strong anticholinergic (drying) and sedative effects. The injection is given \u003cstrong\u003eintravenously (IV) or intramuscularly (IM)\u003c\/strong\u003e when rapid effect is needed or when a patient cannot take oral medication. (In practice the brand “Benadryl” injection has been discontinued, but generic diphenhydramine injections are available\u003c\/p\u003e\n\u003cp\u003eDiphenhydramine injection is used mainly for \u003cstrong\u003eacute allergic reactions\u003c\/strong\u003e, especially in emergency settings. It is given as an adjunct to epinephrine and other therapies in severe allergies (anaphylaxis). It also relieves symptoms of \u003cstrong\u003eallergic and cold-related reactions\u003c\/strong\u003e (e.g. hives, hay fever, nasal and eye symptoms) when the patient cannot take pills. In practice it is often used for \u003cstrong\u003emotion sickness\u003c\/strong\u003e, nausea or vomiting when oral medications can’t be taken. Because of its anticholinergic action, it can also control certain \u003cstrong\u003eextrapyramidal\/withdrawal symptoms\u003c\/strong\u003e – for example, abnormal movements in Parkinsonian syndromes or drug-induced dystonia when oral treatment is not feasible. In short, common indications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere allergic reactions (anaphylaxis):\u003c\/strong\u003e as part of emergency treatment (along with epinephrine).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic relief:\u003c\/strong\u003e for acute allergic or “cold” symptoms (nasal congestion, hives, itching) when oral meds aren’t practical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMotion sickness\/dizziness:\u003c\/strong\u003e to treat nausea, vomiting or vertigo from motion sickness when oral antiemetics cannot be used.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eParkinsonian or extrapyramidal symptoms:\u003c\/strong\u003e for mild cases of Parkinson’s‐type muscle spasms or drug-related movement disorders when other medications can’t be taken.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e(Diphenhydramine injection may be used “off label” for other purposes as directed by a doctor, but these are the primary FDA-approved and common uses.)\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cp\u003eThe drug comes as a 50 mg\/mL solution for injection. Adults are typically given \u003cstrong\u003e10–50 mg by IV or IM\u003c\/strong\u003e. For IV use, the infusion rate should generally not exceed ~25 mg\/min; larger single doses (up to 100 mg IM) may be used if needed. (Maximum total daily doses are around 300–400 mg in adults.) Pediatric dosing is weight-based (e.g. 5 mg\/kg\/day divided into multiple doses). Treatment can be repeated as necessary under medical supervision. Because diphenhydramine can cause significant sedation, injections are usually given in a healthcare setting (hospital\/clinic) or at home only after proper instruction\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003ePatients or caregivers should be shown how to administer the injection (IM or slow IV push) and advised not to exceed recommended rates. The solution should be inspected to ensure it is clear and the correct concentration (50 mg\/mL) before use. (Each ampule\/container is labeled for 1 mL fill = 50 mg USP). Unused solution should be discarded according to guidelines.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSide Effects and Precautions\u003c\/h2\u003e\n\u003cp\u003eDiphenhydramine (especially by injection) commonly causes \u003cstrong\u003ecentral nervous system and anticholinergic effects\u003c\/strong\u003e. Patients often feel \u003cstrong\u003edrowsy, dizzy or lightheaded\u003c\/strong\u003e. Other frequent effects include \u003cstrong\u003eblurred vision or double vision, headache, dry mouth, difficulty urinating, stomach upset, and tremor\u003c\/strong\u003e. Because of these effects, patients should \u003cstrong\u003enot drive or operate machinery\u003c\/strong\u003e until they know how the drug affects them. Alcohol or other sedatives (sleeping pills, narcotics, etc.) should be avoided or limited, as they can greatly increase drowsiness or confusion.\u003c\/p\u003e\n\u003cp\u003eSerious side effects are rare but can include fast\/irregular heartbeat, severe confusion or agitation, seizures, or difficulty breathing. These require immediate medical attention. Elderly patients are particularly sensitive to the sedating and anticholinergic effects; lower doses may be needed. Patients with glaucoma, enlarged prostate, or certain heart problems should use diphenhydramine cautiously because it can worsen these conditions.\u003c\/p\u003e\n\u003cp\u003eBecause diphenhydramine crosses the placenta and passes into breast milk, women who are pregnant or nursing should discuss risks with their doctor. Generally, the doctor will weigh the benefits of treatment against any potential risks to a baby. In pregnancy, diphenhydramine is used if clearly needed (category B). Breastfeeding is usually avoided while on diphenhydramine due to risk of infant sedation.\u003c\/p\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003cp\u003eDiphenhydramine is a \u003cstrong\u003ehistamine H₁-receptor antagonist\u003c\/strong\u003e. Normally, exposure to allergens causes the body to release histamine, which triggers itching, swelling, redness, and mucus production. Diphenhydramine blocks histamine at its receptors, \u003cstrong\u003epreventing or reducing these allergic symptoms\u003c\/strong\u003e. Its strong anticholinergic (muscarinic receptor blocking) properties also dry up mucus and reduce vomiting\/dizziness in motion sickness. Because it is an older “first-generation” antihistamine, it readily penetrates the brain, causing a sedating effect (hence its use as a short-term sleep aid in oral form).\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrand:\u003c\/strong\u003e Avet Pharmaceuticals\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrength:\u003c\/strong\u003e 50 mg\/mL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Single-dose sterile injection\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume per vial:\u003c\/strong\u003e 1 mL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePack size:\u003c\/strong\u003e 25 vials per carton\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNDC:\u003c\/strong\u003e 23155-0264-41\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUPC:\u003c\/strong\u003e 323155264418\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute:\u003c\/strong\u003e Intravenous (IV) or intramuscular (IM) injection\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eDiphenhydramine 50 mg injection\u003c\/strong\u003e is a high-strength antihistamine given by injection when immediate relief is needed or oral therapy is not possible. It rapidly relieves acute allergy symptoms and related conditions through histamine blockade, but it also causes notable drowsiness and anticholinergic side effects. Like all medications, it should be used exactly as prescribed by a healthcare professional, with awareness of the potential side effects and precautions noted above.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNDC:\u003c\/strong\u003e 23155-0264-41 \u003cstrong\u003eUPC:\u003c\/strong\u003e 323155264418 \u003cstrong\u003eBrand:\u003c\/strong\u003e Avet Pharmaceuticals\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eOrder Diphenhydramine Injection 50 mg\/mL 1 mL x 25\/Pack by Avet Pharmaceuticals for Reliable Emergency Allergy Treatment!\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eTrust \u003cstrong\u003eAvet Pharmaceuticals Diphenhydramine Injection\u003c\/strong\u003e for immediate, hospital-grade allergy and anaphylaxis management. \u003cstrong\u003eOrder today\u003c\/strong\u003e for clinical peace of mind in emergencies—ensuring your facility is prepared for any acute allergic crisis!\u003c\/p\u003e","brand":"Avet Pharmaceuticals","offers":[{"title":"Default Title","offer_id":53335169368382,"sku":"23155-0264-41","price":4090.99,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0872\/3408\/5182\/files\/Diphenhydramine-Injection-50-mg-Single-Dose-Vials-1-mL-Avet-Pharmaceuticals.jpg?v=1776752757","url":"https:\/\/himkhand.com\/products\/diphenhydramine-injection-50-mg-ml-single-dose-vials-1-ml-x-25-pack","provider":"Himkhand","version":"1.0","type":"link"}