{"product_id":"aminophylline-for-injection-bronchodilator-250mg-single-dose-vial-10-ml-x-25-tray","title":"Aminophylline for Injection 250 mg Single-dose Vial 10 mL x 25\/Tray (Rx)","description":"\u003cp\u003eAminophylline for Injection 250 mg is a bronchodilator used to treat and manage symptoms of asthma, chronic obstructive pulmonary disease (COPD), and other lung diseases associated with bronchospasm. It works by relaxing the muscles around the airways, improving breathing and airflow in patients experiencing difficulty in breathing. Aminophylline is typically administered intravenously in hospital settings for acute asthma attacks or severe COPD exacerbations, ensuring rapid action to relieve respiratory distress.\u003c\/p\u003e\n\u003cp\u003eAminophylline for Injection by Pfizer Injectables is a bronchodilator used primarily to treat and prevent symptoms of asthma, chronic bronchitis, emphysema, and other lung diseases. It is available in the form of a 250 mg single-dose vial, with a volume of 10 mL per vial. Packaged in a tray of 25 vials, this formulation is intended for intravenous administration to provide rapid relief in acute respiratory emergencies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Aminophylline (a complex of theophylline and ethylenediamine)\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 25 mg\/mL\u003cbr\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e10 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003eTray containing 25 single-dose vials\u003cbr\u003e\u003cstrong\u003eRoute of Administration:\u003c\/strong\u003e Intravenous (IV)\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Primarily used for the treatment of acute asthma attacks, chronic obstructive pulmonary disease (COPD), and other situations requiring bronchodilation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAminophylline works by relaxing the smooth muscles of the bronchial airways and pulmonary blood vessels. It does this by inhibiting phosphodiesterase enzymes, leading to an increase in cyclic AMP levels in the cells. The elevated cAMP helps in relaxing the tracheal and bronchial muscles while decreasing airway reactivity and inflammation. Additionally, aminophylline has mild diuretic effects and central nervous system stimulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTherapeutic Monitoring:\u003c\/strong\u003e Regular monitoring of serum theophylline levels is essential to avoid toxicity, as the therapeutic range is narrow.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Effects:\u003c\/strong\u003e Can cause arrhythmias and palpitations, particularly in patients with pre-existing heart conditions.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeizure Risk:\u003c\/strong\u003e May lower the seizure threshold, especially at supra-therapeutic levels.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e Aminophylline can interact with various drugs, including cimetidine, fluoroquinolones, and certain anticonvulsants, affecting its metabolism.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConditions:\u003c\/strong\u003e Caution is advised in patients with hepatic impairment, heart failure, or hypothyroidism, as these conditions might alter the drug's pharmacokinetics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWhile effective, aminophylline may cause side effects, particularly if serum levels are not properly monitored or if the patient has contraindicating factors:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNausea\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeadache\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eInsomnia\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNervousness or tremors\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCardiac arrhythmias\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSeizures\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSevere hypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGastrointestinal hemorrhage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePatients receiving aminophylline must be closely monitored by healthcare professionals to ensure therapeutic levels are maintained and side effects are minimized. Regular assessment of drug levels, especially during dose adjustments, is critical to avoid toxic effects. Patient-specific factors such as age, weight, and comorbid conditions should guide dosing and monitoring strategies.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":53335035674942,"sku":"00409-5921-01","price":78953.99,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0872\/3408\/5182\/files\/Aminophylline-for-Injection-Bronchodilator-500mg-Single-dose-Vial-10-mL.jpg?v=1776749165","url":"https:\/\/himkhand.com\/products\/aminophylline-for-injection-bronchodilator-250mg-single-dose-vial-10-ml-x-25-tray","provider":"Himkhand","version":"1.0","type":"link"}